Dr MACEDO ROSA Julia – School of Biomedical Sciences

Dr MACEDO ROSA Julia

Assistant Lecturer

juliamacedorosa@cuhk.edu.hk

Biography

Dr MACEDO ROSA Julia obtained her B.Sc. in Pharmacy and Biochemistry, M.Phil., and Ph.D. in Biochemistry from the Federal University of Santa Catarina, Florianopolis, Brazil. Dr. Rosa developed a strong interest in the neurobiology of neuropsychiatric disorders and neurodegenerative diseases, with a focus on depression and Alzheimer’s disease, which was her research focus as a postdoctoral researcher/fellow when she was in Brazil and Hong Kong (The Hong Kong Polytechnic University).

Teaching and Research Interests

Pharmacology education for health professions students (PHAR3413, SBMS2106, MED2400).
Drug Design and Development (SBMS3213) – Course Coordinator.
Neurobiology of neuropsychiatric disorders.
Neurobiology of neurodegenerative diseases.

Selected Publications

Lee, T.H., Devaki, M., Formolo, D.A., Rosa, J.M., Cheng A.S.K. & Yau S.Y. (2023). Effects of Voluntary Wheel Running Exercise on Chemotherapy-Impaired Cognitive and Motor Performance in Mice. International Journal of Environmental Research and Public Health, doi: 10.3390/ijerph20075371.
Camargo, A., Bettio, L.E.B., Rosa, P.B., Rosa J.M., Altê, G.A. & Rodrigues, A.L.S. (2022). The antidepressant-like effect of guanosine involves the modulation of adenosine A1 and A2A receptors. Purinergic Signalling. https://doi.org/10.1007/s11302-022-09898-8.
Rosa, J.M., Formolo, D.A., Yu, Jiasui, Lee, T.H. & Yau, S.Y. (2022). The Role of MicroRNA and Microbiota in Depression and Anxiety. Frontiers in Behavioral Neuroscience, 16, en, 828258.
Rosa, J.M., Camargo, A., Wolin, I.A.V., Kaster, M.P., Rodrigues, A.L.S. (2021). Physical exercise prevents amyloid β 1− 40-induced disturbances in NLRP3 inflammasome pathway in the hippocampus of mice. Metabolic Brain Disease, 36, 351-359.
Camargo, A., Dalmagro, A.P., Fraga, D.B., Rosa, J.M., Zeni, A.L.B., Kaster, M.P. & Rodrigues, A.L.S. (2021). Low doses of ketamine and guanosine abrogate corticosterone- induced anxiety-related behavior, but not disturbances in the hippocampal NLRP3 inflammasome pathway. Psychopharmacology (Berl), p, -14.
Pazini, F., Rosa, J.M., Camargo, A., Fraga, D.B., Moretti, M., Siteneski, A., Rodrigues, A.L.S. (2020). mTORC1-dependent signaling pathway underlies the rapid effect of creatine and ketamine in the novelty-suppressed feeding test. Chemico-Biological Interactions, 332, 109281.
Camargo, A., Dalmagro, A.P., Rosa, J.M., Zeni, A.L.B., Kaster, M.P., Tasca, Carla, Rodrigues, A.L.S.(2020). Subthreshold doses of guanosine plus ketamine elicit antidepressant-like effect in a mouse model of depression induced by corticosterone: role of GR/NF-κB/IDO-1 signaling. Neurochemistry international, 139, 104797.
Rosa, J.M., Pazini, F.L., Camargo, A., Wolin, I.A.V., Olescowicz, G., Eslabao, L., Winkelmann-duarte, E., Rodrigues, A.L.S. (2020). Prophylactic effect of physical exercise on Aβ1-40-induced depressive-like behavior and gut dysfunction in mice. Behavioural Brain Research, 393, electronic number 112791.
Rosa, J. M., Pazini, F.L., Olescowicz, G., Camargo, A., Moretti, M., Gil-mohapel, J., Rodrigues, A.L.S. (2019). Prophylactic effect of physical exercise on Aβ1-40-induced depressive-like behavior: Role of BDNF, mTOR signaling, cell proliferation and survival in the hippocampus. Progress in Neuro- psychopharmacology & biological Psychiatry, 94, electronic number 109646.
Camargo, A., Pazini, F., Rosa, J.M., Wolin, I.A.V., Moretti, M., Rosa, P.B., Neis, V.B., Rodrigues, A.L.S. (2019). Augmentation effect of ketamine by guanosine in the novelty-suppressed feeding test is dependent on mTOR signaling pathway. Journal of Psychiatric Research, 115, 103-112.
Rosa, J. M., Pazini, F.L., Cunha, M.P., Colla, A.R.S., Manossa, L.M., Mancini, G., Souza, A.C.G., Debem, A.F., Prediger, R.D., Rodrigues, A.L.S. (2018). Antidepressant effects of creatine on amyloid β1-40 -treated mice: The role of GSK-3β/Nrf 2 pathway. Progress in Neuro-psychopharmacology & biological Psychiatry, 86, 270-278.
Da fonsêca, V.S., Colla, A.R.S., De Paula, N.C. Placido, E., Rosa, J. M., Farina, M., Gil-mohapel, J., Rodrigues, A.L.S., Brocardo, P.S. (2018). Brain-Derived Neurotrophic Factor Prevents Depressive-Like Behaviors in Early- Symptomatic YAC128 Huntington’s Disease Mice. Molecular Neurobiology, 55, 7201-7215.
Manosso, L.M., Moretti, M., Rosa, J.M., Cunha, M.P., Rodrigues, A.L.S. (2017). Evidence for the involvement of heme oxygenase-1 in the antidepressant- like effect of zinc. Pharmacological Reports, 69, 497-503.
Cunha, M.P., Budni, J., Ludka, F.K., Pazini, F.L., Rosa, J.M., Oliveira, A., Lopes, M.W., Tasca, C.I., Leal, R.B., Rodrigues, A.L.S. (2016). Involvement of PI3K/Akt Signaling Pathway and Its Downstream Intracellular Targets in the Antidepressant-Like Effect of Creatine. Molecular Neurobiology, 53, p.2954-2968.
Pazini, F.L., Cunha, M.P., Azevedo, D., Rosa, J.M., Colla, A.R.S., De Oliveira, J., Ramos-hryb, A.B., Brocardo, P.S., Gil-mohapel, J., Rodrigues, A.L.S. (2016). Creatine Prevents Corticosterone-Induced Reduction in Hippocampal Proliferation and Differentiation: Possible Implication for Its Antidepressant Effect. Molecular Neurobiology, 54, 6245-6260.
Pazini, F.L., Cunha, M.P., Rosa, J.M., Colla, A.R.S., Lieberknecht, V., Oliveira, Á., Rodrigues, A.L.S. (2016). Creatine, Similar to Ketamine, Counteracts Depressive-Like Behavior Induced by Corticosterone via PI3K/Akt/mTOR PATHWAY. Molecular Neurobiology, 53, 6818-6834.
Cunha, M.P., Pazini, F.L., Lieberknecht, V., Budni, J., Oliveira, Á., Rosa, J.M., Mancini, G., Mazzardo, L., Colla, A.R., Leite, M.C., Santos, A.R.S., Martins, D.F. De bem, A.F. Goncalves, C.A.S. Farina, M., Rodrigues, A.L.S. (2016). MPP+-Lesioned Mice: an Experimental Model of Motor, Emotional, Memory/Learning, and Striatal Neurochemical Dysfunctions. Molecular Neurobiology, 54, 6356-6377.
Colla, A.R.S.; Rosa, J.M., Cunha, M.P., Rodrigues, A.L.S. (2015). Anxiolytic-like effects of ursolic acid in mice. European Journal of Pharmacology, 758, 171-176
Cunha, M.P., Pazini, F.L., Rosa, J.M., Ramos-hryb, A.B.; Oliveira, Á., Kaster, M.P., Rodrigues, A.L.S. (2015). Creatine, similarly to ketamine, affords antidepressant-like effects in the tail suspension test via adenosine A1 and A2A receptor activation. Purinergic Signalling, 11, 215-227.
Cunha, M.P., Pazini, F.L., Rosa, J.M., Oliveira, Á., Bettio, L.E.B., Budni, J., Ludka, F. K., Lieberknecht, V., Tasca, C.I. & Rodrigues, A.L.S. (2015). The modulation of NMDA receptors and l-arginine/nitric oxide pathway is implicated in the anti-immobility effect of creatine in the tail suspension test. Amino Acids, 47, 795-811.
Cunha, M.P., Budni, J., Pazini, F.L., Oliveira, Á., Rosa, J.M., Lopes, M.W., Leal, R.B. & Rodrigues, A.L.S. (2014) Involvement of PKA, PKC, CAMK-II and MEK1/2 in the acute antidepressant-like effect of creatine in mice. Pharmacological Reports, 66, 653-659.
Colla, A.R., Oliveira, Á., Pazini, F.L., Rosa, J.M., Manosso, L.M., Cunha, M.P. & Rodrigues, A.L.S. (2014). Serotonergic and noradrenergic systems are implicated in the antidepressant-like effect of ursolic acid in mice. Pharmacology Biochemistry and Behavior, 124, 108-116.
Beringhs, A.O., Rosa, J.M., Budal, R.M., Stulzer, H.K. & Sonaglio, D. (2013). Green Clay and Aloe Vera Peel-Off Facial Masks: Response Surface Methodology Applied to the Formulation Design. AAPS PharmSciTech, 14, 445-455.
Cunha, M.P., Pazini, F.L., Oliveira,Á.; Bettio, L.E.B., Rosa, J.M., Machado, D.G., Rodrigues, A.L.S. (2013). The activation of α1-adrenoceptors is implicated in the antidepressant-like effect of creatine in the tail suspension test. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 44, 39-50.