蔣曉華教授 – 生物醫學學院

蔣曉華教授

Associate Professor

xjiang@cuhk.edu.hk

ORCID

Molecular regulation of adult stem cells.
Stem cell therapy in tissue repair and regeneration.
Crosstalk between stem cells and environment during aging and age-related diseases.
Disease modeling using pluripotent stem cells

Teaching and Research Interests

1. Guo, Y., Guo, D., Zhang, S., Zhang, Y., He, X., Jiang, X., Chan, A. M., Zou, L., Sun, J., & Zhao, H. (2022). Inhibition of PI3 kinase isoform p110alpha suppresses neuroblastoma growth and induces the reduction of Anaplastic Lymphoma Kinase. Cell Biosci, 12(1), 210. doi:10.1186/s13578-022-00946-9.
2. Li, X., Yuan, C., Shi, J., Kang, H., Chen, Y., Duan, Y., Jin, J., Cheung, L. P., Li, T. C., Liu, Y., Cui, Y., Ruan, Y. C., Jiang, X., Cai, Z., Chan, H. C., Ji, L., Zeng, X., Liu, J., Chen, H., & Fok, K. L. (2022). beta-Defensin 19/119 mediates sperm chemotaxis and is associated with idiopathic infertility. Cell Rep Med, 3(12), 100825. doi:10.1016/j.xcrm.2022.100825.
3. Tang, P. C., Chung, J. Y., Liao, J., Chan, M. K., Chan, A. S., Cheng, G., Li, C., Huang, X. R., Ng, C. S., Lam, E. W., Zhang, D., Ho, Y. P., To, K. F., Leung, K. T., Jiang, X., Ko, H., Lee, T. L., Lan, H. Y., & Tang, P. M. (2022). Single-cell RNA sequencing uncovers a neuron-like macrophage subset associated with cancer pain. Sci Adv, 8(40), eabn5535. doi:10.1126/sciadv.abn5535.
4. Mendez-Bermudez, A., Lototska, L., Pousse, M., Tessier, F., Croce, O., Latrick, C. M., Cherdyntseva, V., Nassour, J., Jiang, X., Lu, Y., Abbadie, C., Gagos, S., Ye, J., & Gilson, E. (2022). Selective pericentromeric heterochromatin dismantling caused by TP53 activation during senescence. Nucleic Acids Res, 50(13), 7493-7510. doi:10.1093/nar/gkac603.
5. Weng, Z., Lin, J., He, J., Gao, L., Lin, S., Tsang, L. L., Zhang, H., He, X., Wang, G., Yang, X., Zhou, H., Zhao, H., Li, G., Zou, L*., & Jiang, X.* (2022). Human embryonic stem cell-derived neural crest model unveils CD55 as a cancer stem cell regulator for therapeutic targeting in MYCN-amplified neuroblastoma. Neuro Oncol, 24(6),872-885. doi:10.1093/neuonc/noab241.
6. Bai, S., Lu, X., Pan, Q., Wang, B., Pong, U. K., Yang, Y., Wang, H., Lin, S., Feng, L., Wang, Y., Li, Y., Lin, W., Wang, Y., Zhang, X., Li, Y., Li, L., Yang, Z., Wang, M., Lee, W. Y., Jiang, X., & Li, G*. (2022). Cranial Bone Transport Promotes Angiogenesis, Neurogenesis, and Modulates Meningeal Lymphatic Function in Middle Cerebral Artery Occlusion Rats.Stroke, 53(4), 1373-1385. doi:10.1161/STROKEAHA.121.037912.
7. Huang J, U KP, Yang F, Ji Z, Lin J, Weng Z, Tsang LL, Merson TD, Ruan YC, Wan C, Li G, & Jiang, X.* (2022). Human pluripotent stem cell-derived ectomesenchymal stromal cells promote more robust functional recovery than umbilical cord-derived mesenchymal stromal cells after hypoxic-ischaemic brain damage. Theranostics, 12(1), 143-166. doi:10.7150/thno.57234.
8. Niu, B., Liu, J., Lv, B., Lin, J., Li, X., Wu, C., Jiang, X., Zeng, Z., Zhang, X. K., & Zhou, H. (2021). Interplay between transforming growth factor-beta and Nur77 in dual regulations of inhibitor of differentiation 1 for colonic tumorigenesis. Nat Commun, 12(1), 2809, doi:10.1038/s41467-021-23048-5.
9. Liu, H., Huang, B., Xue, S., U, K.P., Tsang, L.L., Zhang, X., Li, G., & Jiang, X. (2020). Functional crosstalk between mTORC1/p70S6K pathway and heterochromatin organization in stress-induced senescence of MSCs. Stem Cell Res Ther, 11(1), 279, doi:10.1186/s13287-020-01798-1.
10. Huang, B., Wang, B., Lee, Y.W., U, K.P., Leung, K.T., Li, X., Liu, Z., Chen, R., Lin, J.C., Tsang, L.L., Liu, B., Ruan, Y.C., Chan, H.C., Li, G., & Jiang, X. (2019). KDM3A and KDM4C Regulate Mesenchymal Stromal Cell Senescence and Bone Aging via Condensin-mediated Heterochromatin Reorganization. iScience, 21, 375-390, doi:10.1016/j.isci.2019.10.041.
11. Yin, C., Wen, G., Liu, C., Yang, B., Lin, S., Huang, J., Zhao, P., Wong, S.H.D., Zhang, K., Chen, X., Li, G., Jiang, X., Huang, J., Pu, K., Wang, L., & Bian, L. (2018). Organic Semiconducting Polymer Nanoparticles for Photoacoustic Labeling and Tracking of Stem Cells in the Second Near-Infrared Window. ACS Nano, 12(12), 12201-12211, doi:10.1021/acsnano.8b05906.
12. Liu, S., U, K.P., Zhang, J., Tsang, L.L., Huang, J., Tu, S.P., & Jiang, X. (2018). R-spodin2 enhances canonical Wnt signaling to maintain the stemness of glioblastoma cells. Cancer Cell International, 18, 156, doi:10.1186/s12935-018-0655-3.
13. Yang, F.Y., Chen, R., Zhang, X., Huang, B., Tsang, L.L., Li, X., & Jiang, X. (2018). Preconditioning Enhances the Therapeutic Effects of Mesenchymal Stem Cells on Colitis Through PGE2-Mediated T-Cell Modulation. Cell Transplantation, 27(9), 1352-1367, doi:10.1177/0963689718780304.
14. Li, X., Fok, K.L., Guo, J., Wang, Y., Liu, Z., Chen, Z., Wang, C., Ruan, Y.C., Yu, S.S., Zhao, H., Wu, J., Jiang, X.*, & Chan, H.C.* (2018). Retinoic acid promotes stem cell differentiation and embryonic development by transcriptionally activating CFTR. Biochim Biophys Acta Mol Cell Res, 1865(4), 605-615, doi:10.1016/j.bbamcr.2018.01.005.
15. Chen, K., Liu, Q., Tsang, L.L., Ye, Q., Chan, H.C., Sun, Y., & Jiang, X. (2017). Human MSCs promotes colorectal cancer epithelial-mesenchymal transition and progression via CCL5/β-catenin/Slug pathway. Cell Death Dis, 8(5), e2819, doi:10.1038/cddis.2017.138.
16. Chen, R., Lee, W.Y.W., Zhang, X.H., Zhang, J.T., Lin, S., Xu, L.L., Huang, B., Yang, F.Y., Liu, H.L., Wang, B., Tsang, L.L., Willaime-Morawek, S., Li, G., Chan, H.C., & Jiang X. (2017). Epigenetic Modification of the CCL5/CCR1/ERK Axis Enhances Glioma Targeting in Dedifferentiation-Reprogrammed BMSCs. Stem Cell Reports, 8(3), 743-757, doi:10.1016/j.stemcr.2017.01.016.
17. Liu, Z., Guo, J., Wang, Y., Weng, Z., Huang, B., Yu M.K., Zhang, X., Yuan, P., Zhao, H., Chan, W.Y., Jiang, X.*, & Chan, H.C.* (2017). CFTR-β-catenin interaction regulates mouse embryonic stem cell differentiation and embryonic development. Cell Death Diff, 24(1), 98-110, doi:10.1038/cdd.2016.118.
18. Meng, F., Xu, L., Huang, S., Liu ,Y., Hou, Y., Wang, K., Jiang, X.*, & Li, G.* (2016). Small nuclear ribonucleoprotein polypeptide N (Sm51) promotes osteogenic differentiation of bone marrow mesenchymal stem cells by regulating Runx2. Cell and Tissue Research, 366(1), 155-162, doi:10.1007/s00441-016-2411-0.
19. Zhang, J.T., Weng, Z.H., Tsang, K.S., Tsang, L.L., Chan, H.C., & Jiang, X. (2016). MycN is critical for the maintenance of human embryonic stem cell-derived neural crest stem cells. PLoS One, 11(1), e0148062, doi:10.1371/journal.pone.0148062.
20. Rui, Y., Xu, L., Chen, R., Zhang, T., Lin, S., Hou, Y., Liu, Y., Meng, F., Liu, Z., Ni, M., Tsang, K.S., Yang, F., Wang, C., Chan, H.C., Jiang, X.*, & Li G.* (2015). Epigenetic memory gained by priming with osteogenic induction medium improves osteogenesis and other properties of mesenchymal stem cells. Scientific Reports, 5, 11056, doi:10.1038/srep11056.

Co-first author

Selected Publications

RGC – General Research Fund [PI; 01-Jan-23 to 31-Dec-25]: “Functional and mechanistic characterisation of the role of R-spondin3/LGR5 axis in oligodendrocyte development and white matter repair” (HK$1,378,723).
ITSP Tier 3 [PI; 01-Jan-20 to 30-Oct-21]: “Development of nanoparticles encapsulating stem cell secretion for nose-to-brain delivery to promote brain injury repair” (HK$1,396,971).
RGC – General Research Fund [PI; 01-Jan-20 to 31-Dec-22]: “Jmjd1a regulates mitochondrial function of adult neural stem cells and brain aging via PI3K/AKT/mTOR pathway” (HK$1,114,025).
RGC – General Research Fund [PI; 01-Sep-17 to 31-Aug-20]: “Epigenetic and functional characterization of histone demethylases Jmjd1a and Jmjd2c in MSC senescence” (HK$961,571).
RGC – General Research Fund [PI; 01-Jan-17 to 31-Dec-19]: “Role of CFTR in embryonic stem cells and early embryo development: possible regulation of the Wnt/β-catenin signaling” (HK$1,056,150).
Health and Medical Research Fund [PI; 01-Sep-16 to 31-Aug-18]: “Neural Crest Stem Cells: a Novel Source of Cell Therapy for Neontal Hypoxic-ischemic Brain Damage” (HK$1,195,440).
RGC – General Research Fund [PI; 01-Jan-14 to 31-Dec-16]: “CFTR promotes glioma progression via suppression of p53/miR-34a pathway” (HK$840,051).
Health and Medical Research Fund [PI; 01-Jan-14 to 30-Jun-16]: “Rescuing Neonates from Hypoxic-ischemic Brain Injury with Dedifferentiation-resprogrammed Mesenchymal Stem Cells” (HK$1,000,000).
RGC – General Research Fund [PI; 01-Jan-12 to 31-Dec-13]: ” CFTR as a tumor suppressor in breast cancer progression/metastasis” (HK$747,500).
RGC – General Research Fund [PI; 01-Jan-11 to 31-Dec-13]: ” Human embryonic stem cells as tools to investigate the oncogenic basis of MYCN in neuroblastoma ” (HK$1,390,000).

Grants

(EN)

RGC – General Research Fund [PI; 01-Jan-23 to 31-Dec-25]: “Functional and mechanistic characterisation of the role of R-spondin3/LGR5 axis in oligodendrocyte development and white matter repair” (HK$1,378,723).
ITSP Tier 3 [PI; 01-Jan-20 to 30-Oct-21]: “Development of nanoparticles encapsulating stem cell secretion for nose-to-brain delivery to promote brain injury repair” (HK$1,396,971).
RGC – General Research Fund [PI; 01-Jan-20 to 31-Dec-22]: “Jmjd1a regulates mitochondrial function of adult neural stem cells and brain aging via PI3K/AKT/mTOR pathway” (HK$1,114,025).
RGC – General Research Fund [PI; 01-Sep-17 to 31-Aug-20]: “Epigenetic and functional characterization of histone demethylases Jmjd1a and Jmjd2c in MSC senescence” (HK$961,571).
RGC – General Research Fund [PI; 01-Jan-17 to 31-Dec-19]: “Role of CFTR in embryonic stem cells and early embryo development: possible regulation of the Wnt/β-catenin signaling” (HK$1,056,150).
Health and Medical Research Fund [PI; 01-Sep-16 to 31-Aug-18]: “Neural Crest Stem Cells: a Novel Source of Cell Therapy for Neontal Hypoxic-ischemic Brain Damage” (HK$1,195,440).
RGC – General Research Fund [PI; 01-Jan-14 to 31-Dec-16]: “CFTR promotes glioma progression via suppression of p53/miR-34a pathway” (HK$840,051).
Health and Medical Research Fund [PI; 01-Jan-14 to 30-Jun-16]: “Rescuing Neonates from Hypoxic-ischemic Brain Injury with Dedifferentiation-resprogrammed Mesenchymal Stem Cells” (HK$1,000,000).
RGC – General Research Fund [PI; 01-Jan-12 to 31-Dec-13]: ” CFTR as a tumor suppressor in breast cancer progression/metastasis” (HK$747,500).
RGC – General Research Fund [PI; 01-Jan-11 to 31-Dec-13]: ” Human embryonic stem cells as tools to investigate the oncogenic basis of MYCN in neuroblastoma ” (HK$1,390,000).