田小雨教授 – 生物醫學學院

田小雨教授

Assistant Professor

xytian@cuhk.edu.hk

Publons

ORCID

個人簡介

Prof. TIAN Xiaoyu (田小雨) is an Assistant Professor of the School of Biomedical Sciences, The Chinese University of Hong Kong (CUHK). She received PhD from CUHK Department of Physiology. She studied the therapeutic effect of PPARs on vascular dysfunction in hypertension and type 2 diabetes, and mitochondrial oxidative stress in endothelial cell function. After graduation, she continued as a postdoctoral fellow in the Cardiovascular Research Institute, the University of California San Francisco, studying macrophage dynamics in obesity-induced adipose tissue inflammation, and also in the atherosclerosis. She later joined CUHK again as Research Assistant Professor in 2015, and is Assistant Professor since 2017. Her current research interests include the regulation of macrophage function by molecular clock components in the vascular microenvironment of cardiovascular diseases. She also works on adipose tissue inflammation and immune regulation of obesity and insulin resistance.

Teaching and Research Interests

Function of molecular clock in cardiovascular diseases.
Macrophage function in metabolic syndrome.

Selected Publications

Wu, Y., Lin, X., Hong, H., Fung, Y.L., Cao, X., Tse, J.K.Y., Li, T.H., Chan, T.F., Tian, X.Y.* (2022). Endothelium-targeted delivery of PPARδ by adeno-associated virus serotype 1 ameliorates vascular injury induced by hindlimb ischemia in obese mice. Biomedicine & Pharmacotherapy, 151:113172. doi: 10.1016/j.biopha.2022.113172.
Bai, Q., Xiao, Y., Hong, H., Cao, X., Zhang, L., Han, R., Lee, L.K.C., Xue, E.Y., Tian, X.Y.*, Choi, C.H.J.* (2022). Scavenger receptor-targeted plaque delivery of microRNA-coated nanoparticles for alleviating atherosclerosis. Proc Natl Acad Sci U S A, 119(39):e2201443119. doi: 10.1073/pnas.2201443119.
Cao, X., Wu, Y., Hong, H., Tian, X.Y.* (2022). Sirtuin 3 dependent and independent effects of NAD⁺ to suppress vascular inflammation and improve endothelial function in mice. Antioxidants, 11(4):706; doi: 10.3390/antiox11040706.
Cao, H., Chung, A.C.K., Ming, X., Mao, D., Lee, H.M., Cao, X., Rutter, G.A., Chan, J.C.N., Tian, X.Y.*, Kong, A.P.S.* (2022). Autotaxin signaling facilitates β cell dedifferentiation and dysfunction induced by Sirtuin 3 deficiency. Molecular Metabolism , 60:101493. doi: 10.1016/j.molmet.2022.101493.
Wu, Y., Tang, X., Lee, S., Hong, H., Cao, X., Lau, C.W., Liu, B., Chawla, A., Ma, R.C.W., Huang, Y., Lui, K.O., Tian, X.Y.* (2022). Endothelial PPARδ facilitates the post-ischemic vascular repair through interaction with HIF1α. Theranostics, 12(4):1855-1869. doi:10.7150/thno.69017.
Huo, M., Cao, X., Zhang, H., Lau, C.W., Hong, H., Chen, F.M., Huang, Y., Chawla, A., Tian, X.Y.* (2022). Loss of myeloid Bmal1 exacerbates hypertensive vascular remodelling through interaction with STAT6 in mice. Cardiovascular Research, cvab336. doi: 10.1093/cvr/cvab336.
Hong, H., Cheung, Y.M., Cao, X., Wu, Y., Li, C., Tian, X.Y.* (2021). REV-ERBα agonist SR9009 suppresses IL-1β production in macrophages through BMAL1-dependent inhibition of inflammasome. Biochemical Pharmacology, 192:114701. doi: 10.1016/j.bcp.2021.114701.
Cheng, C.K., Luo, J.Y., Lau, C.W., Cho, W.C., Ng, C.F., Ma, R.C.W., Tian, X.Y.*, Huang, Y.* (2021). A GLP-1 analog lowers ER stress and enhances protein folding to ameliorate homocysteine-induced endothelial dysfunction. Acta Pharmacologica Sinica, doi: 10.1038/s41401-020-00589-x.
Ming, X., Chung, A.C.K., Mao, D., Cao, H., Fan, B., Wong, W.K.K., Ho, C.C., Lee, H.M., Schoonjans, K., Auwerx, J., Rutter, G.A., Chan, J.C.N., Tian, X.Y.*, Kong, A.P.S.* (2021). Pancreatic Sirtuin 3 Deficiency Promotes Hepatic Steatosis by Enhancing 5-Hydroxytryptamine Synthesis in Mice With Diet-Induced Obesity. Diabetes, 70(1):119-131. doi: 10.2337/db20-0339.
Tian, D., Hong, H., Shang, W., Ho, C.C., Dong, J., Tian, X.Y.* (2020). Deletion of Ppard in CD11c⁺ Cells Attenuates Atherosclerosis in ApoE Knockout Mice. FASEB Journal, 34(2):3367-3378. https://doi.org/10.1096/fj.201902069r
Yin, B., Chan, C.K.W., Liu, S., Hong, H., Wong, S.H.D., Lee, L.K.C., Ho, L.W.C., Zhang, L., Leung, K.C., Choi, P.C., Bian, L.*, Tian, X.Y.*, Chan, M.N.*, Choi, C.H.J.* (2019). Intrapulmonary Cellular-Level Distribution of Inhaled Nanoparticles with Defined Functional Groups and Its Correlations with Protein Corona and Inflammatory Response. ACS Nano, 13(12):14048-14069. doi: 10.1021/acsnano.9b06424.
Cheang, W.S., Wong, W.T., Wang, L., Cheng, C.K., Lau, C.W., Ma, R.C.W., Xu, A., Wang, N., Huang. Y.*, Tian, X.Y.* (2019). Resveratrol ameliorates endothelial dysfunction in diabetic and obese mice through sirtuin 1 and peroxisome proliferator-activated receptor δ. Pharmacological Research, 139: 384-394. doi: 10.1016/J.PHRS.2018.11.041
Zhang, L., Tian, X.Y., Chan, C.K.W., Bai, Q., Cheng, C.K., Chen, F.M., Cheung, M.S.H., Yin, B., Yang, H., Yung, W.Y., Chen, Z., Ding, F., Leung, K.C., Zhang, C., Huang, Y., Lau, J.Y.W., Choi, C.H.J. (2019). Promoting the Delivery of Nanoparticles to Atherosclerotic Plaques by DNA Coating. ACS Applied Materials & Interfaces, 11(15):13888-13904. https://doi.org/10.1021/ACSAMI.8B17928
Kho, J., Tian, X., Wong, W.T., Bertin, T., Jiang, M.M., Chen, S., Jin, Z., Shchelochkov, O.A., Burrage, L.C., Reddy, A.K., Jiang, H., Abo-Zahrah, R., Ma, S., Zhang, P., Bissig, K.D., Kim, J.J., Devaraj, S., Rodney, G.G., Erez, A., Bryan, N.S., Nagamani, S.C.S., Lee, B.H. (2018). Argininosuccinate Lyase Deficiency Causes an Endothelial-Dependent Form of Hypertension. American Journal of Human Genetics, 103(2): 276-287. https://doi.org/10.1016/J.AJHG.2018.07.008
Huo, M., Huang, Y.H., Qu, D., Zhang, H., Wong, W.T., Chawla, A., Huang, Y., Tian, X.Y.* (2017). Myeloid Bmal1 deletion increases monocyte recruitment and worsens atherosclerosis. FASEB Journal, 31(3):1097-1106. doi: 10.1096/FJ.201601030R.
Cheang, W.S., Wong, W.T., Zhao, L., Xu, J., Wang, L., Lau, C.W., Chen, Z.Y., Ma, R.C.W., Xu, A., Wang, N., Tian, X.Y.*, Huang, Y.* (2017). PPARδ is required for exercise to attenuate endoplasmic reticulum stress and endothelial dysfunction in diabetic mice. Diabetes, 66(2): 519-528. https://doi.org/10.2337/DB15-1657
Tian, X.Y., Ganeshan, K., Hong, C., Nguyen, K.D., Qiu, Y., Kim, J., Tangirala, R.K., Tontonoz, P., Chawla, A. (2016). Thermoneutral housing accelerates metabolic inflammation to potentiate atherosclerosis but not insulin resistance. Cell Metabolism, 23(1):165–178. doi: 10.1016/J.CMET.2015.10.003.
Qiu, Y., Nguyen, K.D., Odegaard, J.I., Cui, X., Tian, X., Locksley, R.M., Palmiter, R.D., Chawla, A. (2014). Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. Cell, 157(6):1292-308. https://doi.org/10.1016/J.CELL.2014.03.066
Tian, X.Y., Wong, W.T., Wang, Y.X., Lee, H.K., Ng, C.F., Chen, Z.Y., Yao, X., Au, C.L., Leung, F.P., Lau, C.W., Vanhoutte, P.M., Cooke, J.C., Huang, Y. (2012). Oxidative stress-dependent cyclooxygenase-2-derived prostaglandin F_2α impairs endothelial function in renovascular hypertensive rats. Antioxidants & Redox Signaling, 16(4):363-73. https://doi.org/10.1089/ARS.2010.3874
Tian, X.Y., Wong, W.T., Xu, A., Lu, Y., Wang, L., Zhang, Y., Cheang, W.S., Wang, Y., Yao, X., Huang, Y. (2012). Uncoupling protein-2 protects endothelial function in diet-induced obese mice. Circulation Research, 110(9):1211-6. https://doi.org/10.1161/CIRCRESAHA.111.262170
Tian, X.Y., Wong, W.T., Wang, N., Lu, Y., Liu, J., Cheang, W.S., Liu, L., Liu, Y., Lee, S.S.T., Chen, Z.Y., Yao, X., Cooke, J.P., Huang, Y. (2012). PPARdelta activation protects endothelial function in diabetic mice. Diabetes, 61(12):3285-93. https://doi.org/10.2337/DB12-0117* Corresponding / Co-corresponding author

Grants

Hong Kong Research Grant Council General Research Fund 22/23. Endothelial expression of PPARδ is protective against endotoxemia induced vascular injury (14107822).
Hong Kong Research Grant Council General Research Fund 21/22. Endothelial expression of Sox4 enhances endothelial dysfunction and promotes atherosclerosis (14105321).
Health and Medical Research Fund 20/21. Investigating the protective effect of statin against vascular toxicity induced by BCR-ABL tyrosine kinase inhibitors (08191156).
NSFC Excellent Young Scientists Fund 優秀青年科學家基金(港澳) 2019. Regulation of vascular homeostasis by PPARD (81922078).
Hong Kong Research Grant Council General Research Fund 19/20. Endothelial SIRT3 mitigates atherosclerosis through regulating mitochondrial protein acetylation (14109519).
Hong Kong Research Grant Council Early Career Scheme 18/19. Inhibition of Circadian Gene Bmal1 in Macrophages Promotes Vascular Inflammation in Hypertension through COX-2 and Prostaglandin F2α (24122318).