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發育及再生生物學
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發育及再生生物學

The Developmental and Regenerative Biology (DRB) Thematic Research Program covers four specific, but complimentary, research areas listed below. Members are interested in the cellular and molecular mechanisms of how embryos, tissues and stem cells are formed, develop, function and degenerate. Also how factors such as signalling molecules, hormones, growth factors and cytokines control these important processes. Outcome of these researches will help how we understand what is needed to recreate tissue and organs, including new drugs that could be used in regenerative medicine.

 

Reproductive Biology

  • Functional genomics and epigenetics in germ cell and gonad development
  • Role of the hypothalamic-pituitary-gonadal axis in health and disease
  • Delineating molecular mechanisms underlying germ cell ageing

 

Developmental Biology

  • Using mouse, Xenopus and zebrafish embryos as models to elucidate fundamental development processes
  • Foetal development in health and disease: genetics, genomics and the development of biomarkers

 

Endocrinology

  • Hormone action and signal transduction
  • Pancreatic physiology and diabetes
  • Endocrine disorders : molecular biology and treatment by stem cells and therapeutic agents
  • Intracellular protein trafficking and hypothalamic/pituitary hormone secretion

 

Stem Cells and Regenerative biology

  • Investigating fundamental biological and mechanical factors that regulate stem cell proliferation, differentiation and developmental fate
  • Use of stem cells and 3D scaffold-printing to generate tissues and organs for regeneration such bone fracture healing, cardiovascular and neural tissue repair etc.
  • Reprograming normal and genetically abnormal somatic cells into induced pluripotent stem cell (iPS) and using them as models to study human diseases and developmental processes
  • Germline stem cell transdifferentiation for tissue regeneration

(EN) Reproductive Biology

(EN)

  • Functional genomics and epigenetics in germ cell and gonad development
  • Role of the hypothalamic-pituitary-gonadal axis in health and disease
  • Delineating molecular mechanisms underlying germ cell ageing
Principal Investigators
Name
Contact No.
Research Interests
(EN) Tissue Engineering, regenerative medicine, biomaterials, stem cells, cell-based therapy, hydrogel, extracellular matrix
陳漢輝教授
(EN) Tissue engineering, liver regeneration, stem cell, microfluidics, biomaterial, biomechanics
陳偉儀教授
(EN) Genetic diseases, germ cells, differentiation, tumor, microRNA, epigenetics
陳活彜教授
(EN) Stem cell therapy, development of enteric nervous system, neural crest stem cells, stem cell migration and differentiation, congenital gut disorders, cell transplantation, mouse embryonicdevelopment, Hirschsprung’s disease, irritable bowel syndrome, neural crest cell induction
張凱鴻教授
(EN) Stem cell differentiation and aging
杜卓勳教授
(EN) Pluripotent and adult stem cells, Cardiac development, Brown and beige adipocytes, Therapeutic development for type 2 diabetes
馮波教授
(EN) Genome editing, Stem cells, Gene and cell therapy, Inherited hematopoietic and metabolic disorders
霍建霖教授
(EN) Infertility, assisted reproduction technologies, male contraceptive, sperm functions, spermatogenesis, germline stem cell biology, germ cell transplantation, testis microenvironment, cancer/testis genes
高波教授
(EN) Skeletal Biology, Skeletal Disorders, Wnt/PCP signaling in development and disease
顧燊教授
(EN) Molecular mechanisms of deleterious genetic alterations in inheritable human diseases
蔣曉華教授
(EN) Stem cell epigenetics, stem cell therapy, stem cell microenvironment, aging
柯岱飛教授
(EN) Muscloskeletal biology, tissue engineering, regenerative medicine, functionally-graded biomaterials, artificial intelligence, machine learning, cell tracking, computer vision
高永雄教授
(EN) Epithelial transport, Ca2+/cAMP signaling, purinergic receptors, Heme oxygenase, carbon monoxide, airway inflammation, fluorescence imaging
岑美霞教授
(EN) Molecular mechanisms of mammalian development and human congenital disorders, transcriptional regulation, functional genomics, craniofacial, inner ear and sensory neural development, neural crest and placode, stem cells and regeneration
段崇智教授
萬超教授
(EN) Bone, cartilage, degeneration, regeneration, stem cells, small molecules, tissue engineering
王丹教授
(EN) Bone tendon tissue engineering, extracellular matrix, stem cells, immunomodulation
夏銀教授
(EN) Kidney physiology, injury and repair, Male reproductive biology, Metabolic signaling pathways in the liver
趙暉教授
(EN) Embryonic development, tumorigenesis of neuroblastoma, tissue regeneration and therapy
Associate Members
Name
Contact No.
(EN) Prof CHAN Chung Ngor Juliana
(EN) Dr CHAN Leung Kwok Clement
(EN) Prof CHENG Chun Yiu Jack
(EN) Prof CHOY Kwong Wai Richard
(EN) Prof LEUNG Ting Fan
(EN) Prof LI Gang
(EN) Prof LI Zhong Alan
(EN) Prof POON Wai Sang
(EN) Prof TANG Leung Sang Nelson
(EN) Prof WANG Huating
主題研究組
概述
腫瘤生物學及實驗藥物治療學
發育及再生生物學
神經、血管、及代謝生物學
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